An Introduction to Injection Therapies


Dr. C. Everett Koop   Former United States Surgeon General

"Prolotherapy is the name some people use for a type of medical intervention in musculoskeletal pain that causes a proliferation of collegen fibers such as those found in ligaments and tendons... I have been a patient who has benefitted from Prolotherapy."

[Prolo Your Pain Away, pg. 15, 1998 edition]

"I continue to see many people who have benefited from Prolotherapy...  In my own case, I had been diagnosed by two separate neurological clinics as having intractable pain. My symptoms and the lack of sleep were affecting my work. I obtained complete relief from prolotherapy. After that, I began using it on the parents of my pediatric patients. I saw remarkable benefits... Certainly, if used properly, prolotherapy does no harm but can be of extraordinary benefit. I have changed many lives."

[quoted from the Prolotherapy Institute]


Types of Injection Therapy

There are a variety of techniques used in the field of injection therapy.  Each technique is focused on providing a different therapeutic effect.  Dr. Reeves' provides this overview of the various injection therapies.  The research on this site specifically focuses on the following three techniques, which are also explained in explained in further detail (PDF).


Prolotherapy:  Promotes the repair of soft tissue in the body through the injection of a non-active "irritant" solution, which prompts swelling to strengthen weakened connective tissue and relieving musculoskeletal pain. Often administered in situations of sports injury or chronic pain, prolotherapy is a natural, low-risk alternative to surgery or joint replacement. "Prolotherapy" refers to the therapeutic effect of promoting the proliferation (growth, formation) of new tissue in areas of damage and pain. By stimulating the body's inflammatory response around the damaged or painful area, the healing process is re-engaged.

Perineural Subcutaneous Injection:  Injection close to subcutaneous (“under the skin”) nerves to restore their normal function. This occurs through affecting another type of inflammation called neuropathic inflammation.   Learn more.

Perineural Deep Injection:   Deeper injection to restore function in pain- producing sensory nerves, often with use of fluid to stretch the nerve in areas of potential compression.



This transcript  provides an excellent introduction to what 
prolotherapy is, how it works, and what conditions it is used to treat.



Video: American Assocation of Orthopaedic Medicine
Dr. Reeves Explains Why He Began Using Prolotherapy



"Dr. Reeves is one of several hundred physicians and osteopaths who specialize in a therapeutic technique called prolotherapy, an alternative medicine method to promote connective tissue repair even years after the damage occurred."
Read The Entire Article

The WSJ quotes Dr. Reeves in this article on prolotherapy.


Read Dr. Reeves' article "Sweet Relief"
featured in BioMechanics Magazine  (PDF)






K. Dean Reeves, M.D. is a physician and medical researcher in the area of pain caused by arthritis, chronic sprains and chronic strains. His private practice is located in the greater Kansas City area of Roeland Park, Kansas.  He collaborates in research with other locations across the country and internationally, and is licensed in the states of Kansas and Missouri.

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Copyright 2011-2014
Dr. K. Dean Reeves

No part of this site should be understood to be personal medical advice or instruction in how to perform injection therapy. A decision on treatment requires a good history and full examination and a knowledge of your treatment goals. Treatment decisions should be made in consultation with your personal healthcare professional and/or prolotherapist.