Fibromyalgia 
Severe Fibromyalgia & Prolotherapy
Reeves KD. Treatment of Consecutive Severe Fibromyalgia Patients With Prolotherapy. The Journal of Orthopaedic Medicine 16(3):84-89, 1994.
12.5% dextrose injection, given extensively under procedural sedation is safe and potentially effective in the treatment of patients with chronic whole body pain that meet the criteria for fibromyalgia.
Our study in Fibromyalgia was published in 1994, based upon the first 2 years of collected data after the primary author learned the technique of reconstructive injection therapy. This was primarily a safety study and the research techniques and measurements were not well developed at that time and this study cannot be used to definitively prove prolotherapy benefit in fibromyalgia. Since then we have learned more effective ways to use prolotherapy in this condition. Combining neural and enthesofascial prolotherapy is more effective. However researching this condition would be very expensive and is not likely to be undertaken for research in a randomized or controlled fashion in the near future. Note also there is much controversy about and yet reason for interest in chronic infectious disorders in this condition, food intolerances, dietary relationships, etc.
The complete text of the study is available in PDF format here.
K. Dean Reeves, M.D. is a physician and medical researcher in the areas of pain caused by arthritis, chronic sprains and chronic strains. His private practice is located in the greater Kansas City area of Roeland Park, Kansas. He collaborates in research with other locations across the country and internationally, and is licensed in the states of Kansas and Missouri.
