Stem Cells

Stem Cells

Increased knee cartilage volume using stem cells

Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician (United States), May-Jun 2008.

Dr. Reeves' Notes:  There is a single case report of use of stem cells for knee injection. This article will be very interesting reading.  The bottom line is that current technology requires harvesting marrow on several occasions and isolating and growing certain types of stem cells in culture since most of the marrow stem cells are not of the preferred type. Obviously, costs are high with this treatment and cost versus benefit will be a consideration as technology improves.  Dr. Centeno did a very good job with this writeup. Naturally diagnosis is absolutely critical with use of stem cells. There are some other studies, but not targeting cartilage and ligament and tendon. 

  • A PDF version of the study is available here, with the publisher's abstract here.
  • I have placed the abstract and comments about this study on the Knee Arthritis page.


K. Dean Reeves, M.D. is a physician and medical researcher in the area of pain caused by arthritis, chronic sprains and chronic strains. His private practice is located in the greater Kansas City area of Roeland Park, Kansas.  He collaborates in research with other locations across the country and internationally, and is licensed in the states of Kansas and Missouri.

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Dr. K. Dean Reeves

No part of this site should be understood to be personal medical advice or instruction in how to perform injection therapy. A decision on treatment requires a good history and full examination and a knowledge of your treatment goals. Treatment decisions should be made in consultation with your personal healthcare professional and/or prolotherapist.